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The precise spatiotemporal control and manipulation of fluid dynamics on a small scale granted by lab-on-a-chip devices provide a new biomedical research realm as a substitute for in vivo studies of host–pathogen interactions. While there has been a rise in the use of various medical devices/implants for human use, the applicability of microfluidic models that integrate such functional biomaterials is currently limited. Here, we introduced a novel dental implant-on-a-chip model to better understand host–material–pathogen interactions in the context of peri-implant diseases. The implant-on-a-chip integrates gingival cells with relevant biomaterials – keratinocytes with dental resin and fibroblasts with titanium while maintaining a spatially separated co-culture. To enable this co-culture, the implant-on-a-chip's core structure necessitates closely spaced, tall microtrenches. Thus, an SU-8 master mold with a high aspect-ratio pillar array was created by employing a unique backside UV exposure with a selective optical filter. With this model, we successfully replicated the morphology of keratinocytes and fibroblasts in the vicinity of dental implant biomaterials. Furthermore, we demonstrated how photobiomodulation therapy might be used to protect the epithelial layer from recurrent bacterial challenges (∼3.5-fold reduction in cellular damage vs. control). Overall, our dental implant-on-a-chip approach proposes a new microfluidic model for multiplexed host–material–pathogen investigations and the evaluation of novel treatment strategies for infectious diseases. 

In this paper, we introduce an oral motion-powered Smart Tooth system that can monitor oral health. Lower pH is an indicator of bacterial accumulation in the oral cavity, which can cause tooth decay, periodontal or peri-implant diseases. Thus, in situ monitoring pH inside of the mouth is critical to prevent oral diseases. Using a piezoelectric dental crown, Smart Tooth system converts oral motions, such as chewing, to electrical power which can impinge a surface integrated LC transponder. The LC transponder also incorporates iron oxide nanoparticles-embedded pH-sensitive hydrogel that modulates the resonant frequency via shrinking or swelling. As a proof of concept, the fabricated prototype measures pH levels ranging from pH 4 to 12 and sends data wirelessly to the receiver placed up to 5 cm away (wireless transmission path loss at 3 cm was 50.79 dB). The results indicate that the Smart Tooth system can monitor oral health while replacing missing teeth.